Smad7 ELISA Kit for Mouse(Mus musculus) | EIAab.comSmad7 ELISA Kit for Mouse(Mus musculus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Smad7(Gene name) > Mouse

Smad7 (Gene name),

Mothers against decapentaplegic homolog 7 (Protein name ), SMAD7_MOUSE from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Smad7(Madh7;Madh8);

Protein name:

Mothers against decapentaplegic homolog 7(MAD homolog 7;Mothers against DPP homolog 7);

Alternative:

SMAD family member 7(SMAD 7;Smad7);Mothers against decapentaplegic homolog 8(MAD homolog 8;Mothers against DPP homolog 8);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with COPS5. Interacts with STAMBP. Interacts with PPP1R15A (By similarity). Interacts with NEDD4L. Interacts with RNF111, AXIN1 and AXIN2. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation (By similarity). Interacts with WWP1.

Function:

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation (By similarity). Ubiquitinated by WWP1.

Subcellular Location:

Nucleus Cytoplasm Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.

Protein Attributes:

Sequence length:

426

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

426:

KGWGQCYTRQ | FISSCPCWLE | VIFNSR

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

KEGG:

mmu:17131

String:

O35253

UniGene:

Mm.34407

SMR:

O35253

Pfam:

PF03165

Uniprot:

O35253

FOR

ELISA Kit for Mouse MAD homolog 7

Cat.:

E0648h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse MAD homolog 7

Cat.:

E0648m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Mouse MAD homolog 7

Cat.:

E0648r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MAD homolog 7

Cat.:

U0648m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MAD homolog 7

Cat.:

U0648r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse MAD homolog 7

Cat.:

U0648h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Mouse MAD homolog 7

Cat.:

P0648Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAD homolog 7

Cat.:

P0648Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse MAD homolog 7

Cat.:

P0648Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse MAD homolog 7

Protein for Mouse MAD homolog 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling."
Nakao A. , Afrakhte M. , Moren A. , Nakayama T. , Christian J.L. , Heuchel R. , Itoh S. , Kawabata M. , Heldin N.-E. , Heldin C.-H. , ten Dijke P.
Nature389:631-635(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue: Placenta.
2.

"Characterization of a novel mouse homologue of Mad, Smad7, that can mediate TGF-beta family signalling."
Kitamura K. , Okazaki K.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue: Embryo.
3.

"Isolation of cDNAs encoding mouse homologues of Mad (Smad7 and Smad7B) that can mediate TGF-beta family signalling."
Kitamura K. , Okazaki K.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)
tissue: Embryo.
4.

"Smad7 selectively interferes with different pathways of activin signaling and inhibits erythroid leukemia cell differentiation."
Kitamura K. , Aota S. , Sakamoto R. , Yoshikawa S.I. , Okazaki K.
Blood95:3371-3379(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B)
5.

"Phosphorylation of Smad7 at Ser-249 does not interfere with its inhibitory role in transforming growth factor-beta-dependent signaling but affects Smad7-dependent transcriptional activation."
Pulaski L. , Landstrom M. , Heldin C.-H. , Souchelnytskyi S.
J. Biol. Chem.276:14344-14349(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-249;MUTAGENESIS OF SER-249;SUBCELLULAR LOCATION
6.

"Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
Koinuma D. , Shinozaki M. , Komuro A. , Goto K. , Saitoh M. , Hanyu A. , Ebina M. , Nukiwa T. , Miyazawa K. , Imamura T. , Miyazono K.
EMBO J.22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF111;UBIQUITINATION
7.

"Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."
Komuro A. , Imamura T. , Saitoh M. , Yoshida Y. , Yamori T. , Miyazono K. , Miyazawa K.
Oncogene23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WWP1;UBIQUITINATION
8.

"NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor."
Kuratomi G. , Komuro A. , Goto K. , Shinozaki M. , Miyazawa K. , Miyazono K. , Imamura T.
Biochem. J.386:461-470(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEDD4L;SUBCELLULAR LOCATION

Product Feedback Wall

* Email:
*Comments: